Robyn Schneider's The Beginning of Everything is a witty and heart-wrenching teen novel that will appeal to fans of books by John Green and Ned Vizzini, novels such as The Perks of Being a Wallflower, and classics like The Great Gatsby and The Catcher in the Rye. Varsity tennis captain Ezra Faulkner was supposed to be homecoming king, but that was before--before his girlfriend cheated on him, before a car accident shattered his leg, and before he fell in love with unpredictable new girl Cassidy Thorpe. As Kirkus said in a starred review, Schneider takes familiar stereotypes and infuses them with plenty of depth. Here are teens who could easily trade barbs and double entendres with the characters that fill John Green's novels. Funny, smart, and including everything from flash mobs to blanket forts to a poodle who just might be the reincarnation of Jay Gatsby, The Beginning of Everything is a refreshing contemporary twist on the classic coming-of-age novel--a heart-wrenching sto...
Platform trials test multiple therapies in one indication, one therapy for multiple indications, or both. These novel clinical trial designs can dramatically increase the cost-effectiveness of drug development, leading to life-altering medicines for people suffering from serious illnesses, possibly at lower cost. Currently, the cost of drug development is unsustainable. Furthermore, there are particular problems in rare diseases and small biomarker defined subsets in oncology, where the required sample sizes for traditional clinical trial designs may not be feasible.
The editors recruited the key innovators in this domain. The 20 articles discuss trial designs from perspectives as diverse as quantum computing, patient's rights to information, and international health.
The book begins with an overview of platform trials from multiple perspectives. It then describes impacts of platform trials on the pharmaceutical industry's key stakeholders: patients, regulators, and payers. Next it provides advanced statistical methods that address multiple aspects of platform trials, before concluding with a pharmaceutical executive's perspective on platform trials. Except for the statistical methods section, only a basic qualitative knowledge of clinical trials is needed to appreciate the important concepts and novel ideas presented.
Product details
- Hardback | 304 pages
- 156 x 235 x 22.86mm | 635g
- 21 Nov 2018
- Taylor & Francis Ltd
- CRC Press
- London, United Kingdom
- English
- 19 Tables, black and white
- 1138052450
- 9781138052451
Download Platform Trial Designs in Drug Development : Umbrella Trials and Basket Trials (9781138052451).pdf, available at ebookdownloadfree.co for free.
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